I'm greatly chuffed everytime I see a more traditional looking Tele. Its just a guitar that can play anything, has just a sound that hits me, there's no middle pickup to interfere in hybrid picking, and you can throw it around and it will still look at you and say, "Right right weeeeee that was fun but so are we gonna slam that combo again with a Blues in Bb?"
Then you switch it to the bridge, hit a distortion pedal and you can go all shreddy or Van Halen and it will take it.
Yes the controls are harder to reach, changing pickups smoothly in a song is pretty difficult stock, it's a more difficult guitar to control, but it's these idiosyncrasies and the tone of a good Tele that gives it character.
You can mod it anyway you want and add any amount of pickups in any position, and it will still be a Tele sound that can somewhat sound like a Strat or a jazz box with a sting, even a chiming parlor acoustic.
You practice hard enough, it rewards you tenfolds.
But I love Strats, I love Les Pauls and 'Birds, I love a good 335 or a 175, I love James Tylers and Taylor acoustics and 80s Ibanezs and JEMs and Valley Arts and Don Grosh and Van Zandt, I wouldn't mind owning a SG, and would love to have a Dobro and learn pedal steel....
I love guitars. But you ask me take one and only one, a Tele with preferably a P90 neck and a slammin' bridge is all I need.
Maybe with a Gatton Notch.
Maybe a G-Bender.
Or not, and it will still be ok~