Single coils are bright, snappy, glassy... basically have a higher end frequency ring to it. However, they also have a tendency to emit a hum.
Humbuckers are actually 2 singlecoils, with one in reverse wound to the other, thus effectively cancelling out the hum. With humbuckers though, the opposite spectrum occurs: fatter, warmer, fuller sound but lacks the brightness of single coils.
Of course, for humbuckers, there's always the split coil mode, but that's worthy of another topic...
In the end, I would say... best try them both and hear for yourself?
There are a lot of guitars with both single coils and humbuckers. You probably need to try only 2.