16k and alnico? Reminds me of a Tonezone. Could get a touch muddy or too dark, even on a bright guitar.
At the end of the day, you gotta take into consideration the guitar, and put more emphasis on it. Reason being, there's only so much a pup can do. It might be un-natural sounding, to put in a bright pup into a dark guitar, but it might just be what the guitar needs. So.. you really have to make sure you balance it up. Too extreme on the pup character, it starts sounds weird.
Anyway, for todays' context, with so many hi gain amps, and pedals around, I don't think there is a need to go for high output pups. Reason being, high output, usually lacks in the cleans dept. Also you really take away the dynamics/responsiveness and add compression from the root of your tone, your guitar. When you do so, then you can't ADD dynamics you know? Its gone already.
I think a wise and practical way is medium/low output pups which have good dynamics/little compression, then use pedals to boost like crazy.
Of course, all the above in the view of a player who wants versatility and dynamices.