Pedals because there's only 1 amp that has a distortion tone I really like, and thats only what I hear from CDs and Live recordings, haven't even got the chance to try one, so I still might not like it in the end!
definetly effect pedals + a clean amp drive. im still a fan of marshall overdrives tho', so sometimes i would switch to the channel with a footswitch.
but i would love to do it like zakk wyldde does, using the overdrive/distortion as a booster to make the dirty amp drive a screaming wailing machine of death...hehe
i gave up a marshall dsl 401 tube combo and a vintage fender twin for a bunch of pedals driving each other into a peavey envoy 110..but now i don't need to drag a heavy ass amp to gigs.