Guitar PLayer January 2003 magazine does a cover on Santana's new rig.
This was the article covering his latest tones on his new album "Shaman", in which he used a Dumble amp through a Brown Soun 4x12 (w/ Tone Tubby 12' speakers) in addition to the Mark 1 1x12 (w/ a 417 Altec speaker).
I'm not sure what combination he plays both in as in his words;
"Like a singer, you want belly tones, chest tones, throat tones, nasal tones and head tones from your guitar. With its 12' Altec, the Boogie is a soprano. It gives me throat, nasal and head tones. But now because I use four 12s with the Dumble head, I get the Pavarotti and Placido Domingo belly tones".
If you listen to the Santana's albums through the years, his tone has changed quite a bit.
However, if you're aiming for his tone in the older records. you can get very close with any Mesa Mark-model amp and a Les Paul/PRS styled guitar.
I used to have a Mesa Mk3 amp and I was surprised to hear how close the tone was to the original records. Spooky.