My reccomendation:
Neck - Lil 59
Middle - Hot Rails
Bridge - JB
And, if you like, coil tap all three for even more fun. I did.
Lil 59, its the most "polite" pickup among those three. Has the sound of a good old PAF humbucker, if you ask me. Warm. I use it for my less agressive songs, such as stuff with light vintage distortion.
Hot Rails, pretty much a heavy pickup. Never tried it, should sound good. Looks bloody good too. You didn't specify what you wanted for middle, so I just reccomended something I thought would be cool. If you want something lighter, maybe a Quarter Pounder or a Vintage Stacked?
JB. Definitely a must have. I have a JB in the bridge of my Ibanez RG1550 and I'm in love with it. Everything I wanted from a metal pickup.
And if I may say, whatever pickup you get, your sound depends heavily on the rest of your rig as well. Let's say you're a vintage freak. All your distortion and EFX are tweaked for a very nice vintage sounding distortion. Obviously if you put in a vintage pickup it will sound excellent. But it also doesn't mean that if, for example, you use a JB it will sould like shit. It will still sound pretty decent.