dude, i use a pod xt live and i set mine up this way Guitar>Pod XTL>effects Return. this bypasses the onboard eq and in most cases everything including the volume is controlled by your mutli efx. so the amp is just kinda like a PA.to me this is the best, as i want my patches to sound as they are when i set them without the intereference of the onboard eq of the amp. much easier. but do keep in mind, diff amp speakers produce different tones so it wont sound exactly the same as your amp at home even it you use the multi efx as the amp modeller.