Actually I use drop-D because sometimes I need it, and since I don't use a Floyd Rose type guitar, I can explore alternative tunings without any issues. So you can actually use both. Just take care to use a fixed-bridge guitar. On a light tremolo, you might have to re-tune all the other strings as well as downtuning one string would make the others go a bit out of whack. Downtuning on a Floyd Rose without proper set-up will ultimately cause tuning, intonation, whatever problems out there.
So if you use fixed-bridge or light tremolo guitars, you should be able to use both. Just take the time to retune, thats all. For the least trouble, use a fixed-bridge guitar.