For some amps though, no baising is needed. I have 2 tube amps at home, one´s a Mesa/Boogie, the other a Fender. For Mesa/Boogie amps, all the their amps are fix biased so you´ll juz have to plug in Mesa tubes, however, you could adjust the bias on the Mesa like other tube amps to accommodate to other types of power tubes though its not recommended by Randall Smith in his manual, but hell, haha... I´ll juz try another power tube other than Mesa, maybe Groove Tubes, EH or JJ,