Where pre-amp valves are concerned, the most common fault is microphony : a high pitched whistling noise which is apparent all the time, whether anything is plugged into the amp or not. This is often caused by the first pre-amp valve in the chain and can sometimes be cured by simply swapping pre-amp valves around. Other pre-amp valve related problems include; lack of volume, loss of bottom end, thinning of the sound and loss of all top-end frequencies. Again it is best to replace all the pre-amp valves at the same time.