In my case, although Im just plain lazy and plugged straight to comp, I'll still say so anyway.
I find that my Landmine Distortion Pedal (use Mix output instead of normal output) works very well with my TS7 especially if your playing lead.
It sounds excellent in position 4 (neck+mid) on my Squier Strat.
I've yet to try it on the amp (im a lazy lazy guy). Will do so soon though. That is, when I have the time. Hhaha.