depends on electronics & wood used right?
i would assume u're talking about LPs with "superstrat" H-H or H-S-H guitars.
neck profile usually is different. LP tend to have thicker necks. also tend to be set-necks, although not always the case.
H-H guitars usually come with a tremolo bridge, while LPs usually are fixed bridge or use a bigsby tremolo.
LPs tend to be heavier than H-H guitars.