Never played a real (Fender) strat.. in fact quite dislike strats personally (sorry!
![Big grin :D :D](https://cdn.jsdelivr.net/joypixels/assets/8.0/png/unicode/64/1f600.png)
).. but from playing Ibanez's, Les Pauls and other guitars, the conclusion I've drawn based on a lot of listening and reading is that the neck pickup gives you thick, fat, chunky low-mid-heavy sound which is very useful for rhythm and barre / power chords. The
bridge pickup on the other hand, is a more treble-heavy tone, that could come in handy when shredding higher up on the neck, doing pinch harmonic bends / squeals, etc.
Then again, you could also very well use the
neck pick up for similar stuff, but it will give you a very different sound and feel, which you can't always realise while you're playing but if you record it and listen back, the change may just be more prominent.
I've noticed that if you use your neck pickup for leads higher up, and just switch to the bridge pickup for a few high bends or licks and then switch back to the neck pick up, it adds great tonal character and variation to your leed.
Apart from all this -- remember that your volume and tone knobs are your friends! While the thought of meddling with them during a song might seem difficult and unnecessary to most beginners, slight tweaks here and there can make a world of difference to the feel, tone and your performance. The volume knob, depending on your pedal chain, amp, and style of playing, could double up as a sort of a gain / drive control and make a remarkable difference to your tone without touching your amp or pedals. For instance, if you're using normal distortion (not too much of it like a rectifier!), you can pull down the volume a few notches to get a nice clean, moderate overdrive tone which can sound amazing if you do it right.
So yea, just play around.. see how each pickup responds with different volume / tone settings and figure out what works best for you.