I heard the ME-50, and I like it. It doesn't sound all that digital.
The main difference between ME-50 and most other multifx these days is that it is built as an effects gadget... without trying to emulate AMPS, which I feel can sometimes be too much of an overkill if not used correctly. ME-50 is made to complement the amp you are using, while other effects "adds" amp sound so as to give a stack coloration.
I would say what others would say to you: try out the multi fx pedals mentioned and choose the one you like the most in ratio to your budget.