im havent tried it myself but based on what others said, it won't usually. It will sound way off than a guitar sound. Although playing music like guitar-based music sounds good on monitors but the problem is that, monitors are meant to play out equal volume throughout a big range of frequencies. Guitar speakers are special such that they are usually very pronounced in the mids. That this into context and you will realise that the sound of the guitar will sound very different from our conventional idea of a guitar sound that most people will not like.
Ive always wondered bout this question myself, and soon ill be conducting something like this, im gonna rewire some home stereo speakers into a guitar amp and see how it sounds.