no negative outcome if you employ non-standard tuning to your guitar. or that you changed your mind later & revert to the original tuning. or that it becomes fashionable to detune the guitar again when a certain band come into highlight. or... you get the pic.
i am reinforcing what CJ said above- with every detune/ string gauge change, there is a need to re-set up the instrument so that it adapts to this quirk.