Set up will involve adjusting the truss rod, pickup height and the Floyd Rose tremolo if you have one. If you change to a different gauge of strings, unstable Floyd Rose or when you want lower string action etc. Intonation will be adjusted at the bridge to lower the action. Setup will cost you from $40 to $100 plus depends on the amount of job needed. You can get your guitar setted up nicely if you bring it to the right person. My favorites are Beez and Mike. Do check them out.