recording engineers would tell you that, if your strings don't run parallel to your pickup's pole pieces, it wouldn't pick up as much string vibrations, so volume issues arise. however, this is more applicable if you record straight-through, ie: ampless. your (cranked) amp would compensate any volume discrepancies IMO.
George Lynch initially had non-trembucking pickups in his ESP guitars & he lived through the Lynch Mob recordings fault-free...